G Protein Coupling and Second Messenger Generation Are Indispensable for a Metalloprotease-dependent Hb-egf Shedding through Angiotensin Ii Type-1 Receptor
نویسندگان
چکیده
From 1 Cardiovascular Research Center, 2 Department of Physiology and 3 Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, 4 Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, 5 Department of Medical Biochemistry, Ehime University School of Medicine, Ehime 791-0301, Japan, 6 Molecular Endocrinology Laboratory, Baker Medical Research Institute, Melbourne 8008, Australia, 7 Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, and 8 Pacific Northwest Research Institute, Seattle, WA 98122
منابع مشابه
G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor.
A G protein-coupled receptor agonist, angiotensin II (AngII), induces epidermal growth factor (EGF) receptor (EGFR) transactivation possibly through metalloprotease-dependent, heparin-binding EGF (HB-EGF) shedding. Here, we have investigated signal transduction of this process by using COS7 cells expressing an AngII receptor, AT1. In these cells AngII-induced EGFR transactivation was completely...
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BACKGROUND Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells (VSMCs) via epidermal growth factor (EGF) receptor (EGFR) transactivation mediated through a metalloprotease-dependent shedding of heparin-binding EGF-like growth factor (HB-EGF). However, the identity of the metalloprotease responsible for this process remains unknown. METHODS AND RESULTS To identify the metal...
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Background—Angiotensin II (Ang II) promotes growth of vascular smooth muscle cells (VSMCs) via epidermal growth factor (EGF) receptor (EGFR) transactivation mediated through a metalloprotease-dependent shedding of heparinbinding EGF-like growth factor (HB-EGF). However, the identity of the metalloprotease responsible for this process remains unknown. Methods and Results—To identify the metallop...
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Glomerular matrix accumulation is a hallmark of diabetic nephropathy. We showed that transactivation of the epidermal growth factor receptor (EGFR) is an important mediator of matrix upregulation in mesangial cells (MC) in response to high glucose (HG). Here, we study the mechanism of EGFR transactivation. In primary MC, EGFR transactivation by 1 h of HG (30 mM) was unaffected by inhibitors of ...
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Communication between different signaling pathways enables cells to coordinate the responses to diverse environmental signals. Activation of the transmembrane growth factor precursors plays a critical role in this communication and often involves metalloprotease-mediated proteolysis. Stimulation of G protein-coupled receptors (GPCR) transactivates the EGF receptors (EGFRs), which occurs via a m...
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تاریخ انتشار 2005